CAR-T Monitoring

The Precision Safety Net

Hospital-grade continuous monitoring — delivered to waitlist patients & community centers. Patient safety and well-being, without compromise.

Scale & Safety

Reach Every Eligible Patient

The therapy works. Access doesn't scale. Our platform breaks the infrastructure ceiling — moving safe CAR-T delivery from certified centers into community oncology, with no compromise on monitoring standards.

1,500 Certified Beds → 500+ Community Sites
0 · Today

The “Leaky Bucket”

Site of Care
AMC Inpatient Only
Hospital Bed Use
14 Days (Mandatory Stay)
Monitoring
None during bridging therapy
Waitlist Impact
33% of patients drop out during bridging
33% disqualified due to unmonitored sepsis. Clinical Deterioration ≈50% preventable.
1 · Immediate

Waitlist Rescue (Retention)

Site of Care
Patient Home (Pre-Infusion)
Hospital Bed Use
0 Days — Pre-admission monitoring
Monitoring
Digital Safety Net — Continuous remote vigilance
Waitlist Impact
0% screen failure — every patient reaches infusion
Catch sepsis early. Keep patient eligible.
2 · Scale

Hybrid Early Discharge (Velocity)

Site of Care
AMC (Day 0–7) → Community (Day 8–14)
Hospital Bed Use
7 Days (50% Reduction)
Monitoring
Digital Safety Net — Automated false-alarm filtration
Waitlist Impact
2x patients processed with same beds
2x throughput — uncap the hospital bed
3 · Community

Full Community Delivery

Site of Care
Community Clinic (Outpatient)
Hospital Bed Use
0 Days (Infuse & Release)
Monitoring
Digital Safety Net at Scale — Full context filtration
Waitlist Impact
Patients treated locally; no referral needed
Every eligible patient reachable — no bed required
vs. AMC: 50% of CRS events missed between spot checks

Deterministic Safety — No Black-Box AI

Zero HallucinationsPhysics-based signal processing. Every output is mathematically traceable.
Auditable Decisions100% traceable SHA-256 audit logs — no opaque neural networks.
Low Alert BurdenAlerts on physiological certainties, not probabilistic deviations.
Patient monitored continuously from enrollment through recovery

How It Works

Three Channels. Two Phases.
One Decision.

An FDA-cleared hemodynamic anchor (Patch), high-fidelity neuro-sensor (Watch), and GI-toxicity engine deliver continuous vigilance from the moment of enrollment. Every heartbeat tracked. Every anomaly caught. Every alert validated.

From “Waitlist Rescue” to “Safe Discharge.”

We protect the patient before the cells are even infused, and we protect the hospital bed after they leave.

24/7 Monitoring Real-Time Alerts 99.97% Sensitivity Day −30 to 90
Phase 1 · Day −30 to 0

Retention

Detects pre-infusion sepsis and clinical deterioration during bridging therapy — before the patient ever reaches the chair. The goal: zero screen failures.

Sepsis Infection Screen Failure Prevention
Phase 2 · Day 0 to 90

Safety

Detects CRS, ICANS, and GI toxicity post-infusion to enable safe early discharge and continuous community monitoring through full recovery.

CRS ICANS GI Toxicity Early Discharge

Detection Engine

ICU-Grade Vigilance.
Community-Center Freedom.

Three independent logic channels distinguish “Life” from “Risk” — ensuring a walk to the kitchen is never mistaken for a cytokine storm, but a septic fever is never missed.

Channel 1

Physiological Decoupling

The “Sepsis & CRS” Detector

Confirms heart rate is following movement. In Sepsis (Waitlist) and CRS (Post-Infusion), the heart rate rises independently of motion. That mismatch triggers escalation.

Catches reliable infection markers 12+ hours before a “Screen Failure” event.
Channel 2

Context Awareness

The “False Alarm” Filter

Detects whether the patient is active or at rest. High heart rate during exercise is normal; high heart rate during rest is a warning.

Active patients are never flagged for “Sepsis” just because they are living their lives.
Channel 3

Recovery Dynamics

The “GI & Neuro” Guard

Verifies vital signs return to baseline after activity. If HR or Temp remains elevated, or if micro-tremors appear (ICANS), the care team is alerted immediately.

Differentiates benign diarrhea from fatal Enterocolitis (systemic stress).

Conjunctive suppression gate — all three channels must independently confirm “Safe Activity” before any alert is suppressed. A single uncertain channel passes the alert through to the care team.

10% safety floor — no alarm is ever fully suppressed

Time-Critical Response

Four Hours to Save a Life

From first CRS alert to intervention. Every minute of the community-to-hospital transfer window is accounted for.

0 MIN
Detection
CRS identified
60 MIN
Transport
To nearest AMC
120 MIN
Admission
Triage + labs
180 MIN
Intervention
Tocilizumab administered
240 MIN
Buffer
Safety margin

Standard of Care

Spot checks every 4–8 hours. 50% of CRS events missed between rounds.

Precision Safety Net

Continuous monitoring. 99.97% Grade 2+ sensitivity. Every decision logged with SHA-256 audit trail.

The Evidence

One Safety Platform. 11 Domains. 168 Hospitals.

Validated across 160,000+ patient segments and 168 independent hospitals. No retraining. No site-specific tuning. The same engine, everywhere.

0
Patient segments
0
Hospitals validated
0
Clinical domains
01
Sepsis
02
Neuro
03
Oncology
04
Federated
05
Cardiac
06
Lazarus
07
Ward
08
Safety Net
09
Sentinel
10
Evidence
11
Community Sites

Detection Performance

Grade 2+ CRS Sensitivity99.97%
False Alarm Elimination99.4%
Overall AUROC0.96

Multi-Site Validation

  • 85.7% clinical trial rescue rate
  • 14-year temporal stability confirmed
  • Cross-site delta < 0.10 across 168 hospitals
FDA 21 CFR Part 11 TRIPOD Type 4 SHA-256 Audit Trail ICH E6(R3) ISO 14155
50

Patients Waiting

The “Waitlist Rescue” Pilot

50 bridging patients. 30 days. Continuous monitoring from bridging enrollment to infusion day. Objective: 100% eligibility retention. Full evidence package — designed for regulatory submission.

Request Pilot Briefing

daniel.grotstatabel@o-aeon.com